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That many people gain weight as they grow older has been a medical issue for a long time and the researchers have difficulty in coming up with a reasonable answer. It is true many elderly people struggle hard to keep their weight in control. Now, medical research has solved the mystery. What has made them gain weight when they cross middle age? The culprit is lipid and when its turnover in the fat tissue decreases as part of ageing, weight gain occurs. People tend to put on weight no matter whether they are on diet and do more or exercise less than before.
Now new research at Karolinska Institutet in Sweden has come up with the relevant answer for the weight gain among elders. The decline of lipid turnover in the fat tissue during ageing triggers weight gain. Neither exercise nor diet will retard the weight gain. The study is published in the journal Nature Medicine.
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The researchers also covered women 41 and examined their lipid turnover; these women underwent bariatric surgery. They studied how the lipid turnover rate affected their ability to keep the weight off four to seven years after surgery. The result revealed that only those who had a low rate before the surgery some how managed to increase their lipid turnover and maintain their weight loss. The researchers are of the opinion that these people might have had more room to increase their lipid turnover than those who already had a high-level before surgery.
"The results indicate for the first time that processes in our fat tissue regulate changes in body weight during ageing in a way that is independent of other factors," according to Peter Arner, professor at the Department of Medicine in Huddinge at Karolinska Institute and one of the main authors in this study on age related weight gain. "This could open up new ways to treat obesity."
Early researchers pointed out that more physical exercise is an important step to speed up the lipid turnover in the fat tissue. This important research throws light on the long-term result of weight-loss surgery and how it could be improved if combined with increased physical activity.
All over the world "Obesity'' is a major problem and the obesity-related diseases have gone up due to many factors, one being due to sedentary life and the other one is caused by fatty, Carbohydrate rich fast food. According to Kirsty Spalding, senior researcher at the Department of Cell and Molecular Biology at Karolinska Institute and another co researcher in this study, ''Obesity is a global problem and "understanding lipid dynamics and what regulates the size of the fat mass in humans has never been more relevant." A strange fact is it is estimated that the number of people suffering from obesity and overweight is significantly higher than the number of people who are underweight. Ageing is a reality of life and no body can escape from it. As people get older, they become more at risk of developing complications like cardiac problems, diabetes, osteoporosis, respiratory diseases than the average middle aged adult. These are common health issues that the average elderly persons need to face as they continue to get older. Adding weight just due to ageing is an added problem for the senior citizens, particularly women. This medical issue needs further scrutiny.
The Stockholm County Council, the Swedish Research Council, the Strategic Research Program for Diabetes at Karolinska Institutet, the Novo Nordisk Foundation, the Swedish Diabetes Foundation, Karolinska Institutet-Astra Zeneca Integrated Cardiometabolic Center, the Vallee Foundation, the Swedish Society of Medicine, the Erling-Persson Family foundation and IXXI gave grants for this significant research.
Story Source and Journal Ref:https://www.sciencedaily.com/releases/2019/09/190909193211.html
P. Arner, S. Bernard, L. Appelsved, K.-Y. Fu, D. P. Andersson, M. Salehpour, A. Thorell, M. Rydén, K. L. Spalding. Adipose lipid turnover and long-term changes in body weight. Nature Medicine, 2019; 25 (9): 1385 DOI: 10.1038/s41591-019-0565-5
Karolinska Institutet. "Why people gain weight as they get older." ScienceDaily. ScienceDaily, 9 September 2019. <www.sciencedaily.com/releases/2019/09/190909193211.html>.